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Confirming refresh will remove any changes you made to issues, query JIRA for updates made to them and insert them into your worksheet and remove all new issues you were about to create. 

 There's a quick way to  To go directly to an particular issue in Jira Software (it gets opened in a web browser), after clicking any , click on its issue key (highlighted in blue hyperlink from "Key" column). 

Refreshing selected issues 

If you want to clean  get updates from only some of the issues, while preserving the changes made to the rest of them, select issues you want to refresh and click Refresh Selected Issues button (2). Just like when refreshing the whole sheet, this will discard all changes made to the selected issues , as well as and update them with the latest changes from JIRA.

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Refreshing single issue from selected issue tab

After clicking a particular issue (1) that is present in a row, user is to be taken for to a Tab view that is dedicated only for that particular issue (2):

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Anything that is to be changed here, is to be applied only for an entitled in the tab issue. Other issues won't be affected when user decides to press "Send Issue to Jira" button (3), or if he/she decides to decides to use "Refresh issue" button (43).

 Note that both buttons use the button uses single form ("issue") to underline that only one, selected, is to be affected by modifications of its content.